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Issue 8, 2014
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Fish in chips: an automated microfluidic device to study drug dynamics in vivo using zebrafish embryos

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Abstract

Interference of the Hedgehog (Hh) signaling pathway by cyclopamine leads to abnormal embryonic development. We monitor this dynamical drug effect in zebrafish embryos with highly precise microenvironment control using an integrated microfluidic device. This chip-based platform, which is programmable and automated, greatly facilitates the accuracy and reproducibility of the in vivo assays.

Graphical abstract: Fish in chips: an automated microfluidic device to study drug dynamics in vivo using zebrafish embryos

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Publication details

The article was received on 24 Sep 2013, accepted on 13 Nov 2013 and first published on 13 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47285J
Citation: Chem. Commun., 2014,50, 981-984
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    Fish in chips: an automated microfluidic device to study drug dynamics in vivo using zebrafish embryos

    C. Zheng, H. Zhou, X. Liu, Y. Pang, B. Zhang and Y. Huang, Chem. Commun., 2014, 50, 981
    DOI: 10.1039/C3CC47285J

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