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Issue 1, 2014
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Examination of native chemical ligation using peptidyl prolyl thioesters

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Abstract

Peptidyl prolyl thioesters, which have been regarded as too unreactive for practical use in native chemical ligations (NCLs), were proven to be versatile reagents in peptide coupling. Tuning the reactivity of prolyl thioesters enabled a one-pot/sequential NCL reaction based on kinetically controlled ligation.

Graphical abstract: Examination of native chemical ligation using peptidyl prolyl thioesters

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Publication details

The article was received on 22 Sep 2013, accepted on 18 Oct 2013 and first published on 22 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC47228K
Citation: Chem. Commun., 2014,50, 58-60
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    Examination of native chemical ligation using peptidyl prolyl thioesters

    T. Nakamura, A. Shigenaga, K. Sato, Y. Tsuda, K. Sakamoto and A. Otaka, Chem. Commun., 2014, 50, 58
    DOI: 10.1039/C3CC47228K

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