Issue 2, 2014
From the journal:

Chemical Communications

Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes†

Agrinaldo Nascimento, Jr.,a   Frederico J. S. Pontes,a   Roberto D. Linsa  and  Thereza A. Soares*a  

* Corresponding authors

a Department of Fundamental Chemistry, Federal University of Pernambuco, Cidade Universitária, Recife, Brazil
E-mail: thereza.soares@ufpe.br

Abstract

The supra-molecular structure of LPS aggregates governs outer membrane permeability and activation of the host immune response during Gram-negative bacterial infections. Molecular dynamics simulations unveil at atomic resolution the subtle balance between cation hydration and cross-linking ability in modulating phase transitions of LPS membranes.

Graphical abstract: Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes

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Article information

DOI
https://doi.org/10.1039/C3CC46918B
Article type
Communication
Submitted
10 Sep 2013
Accepted
24 Oct 2013
First published
29 Oct 2013

Chem. Commun., 2014,50, 231-233

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Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes

A. Nascimento, F. J. S. Pontes, R. D. Lins and T. A. Soares, Chem. Commun., 2014, 50, 231 DOI: 10.1039/C3CC46918B

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