Issue 4, 2014
From the journal:

Chemical Communications

Activation of cell-penetrating peptides by disulfide bridge formation of truncated precursors†

Saskia A. Bode,a   Rike Wallbrecher,b   Roland Brock,b   Jan C. M. van Hesta  and  Dennis W. P. M. Löwik*a  

* Corresponding authors

a Radboud University Nijmegen, Institute for Molecules and Materials, Bio-organic chemistry, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
E-mail: d.lowik@science.ru.nl
Fax: +31 (0)24 3653393
Tel: +31 (0)24 3652382

b Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Post 286, PO Box 9101, 6500 HB Nijmegen, The Netherlands

Abstract

A small library of oligoarginine peptides equipped with terminal cysteines was studied with respect to their cell-penetrating properties. The peptides themselves were inactive but gained the ability to enter cells upon extension of their sequence through disulfide bridge formation.

Graphical abstract: Activation of cell-penetrating peptides by disulfide bridge formation of truncated precursors

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Article information

DOI
https://doi.org/10.1039/C3CC46826G
Article type
Communication
Submitted
06 Sep 2013
Accepted
30 Oct 2013
First published
31 Oct 2013

Chem. Commun., 2014,50, 415-417

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Activation of cell-penetrating peptides by disulfide bridge formation of truncated precursors

S. A. Bode, R. Wallbrecher, R. Brock, J. C. M. van Hest and D. W. P. M. Löwik, Chem. Commun., 2014, 50, 415 DOI: 10.1039/C3CC46826G

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