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Issue 98, 2013
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Engineered P450pyr monooxygenase for asymmetric epoxidation of alkenes with unique and high enantioselectivity

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Abstract

A triple mutant of P450pyr monooxygenase (P450pyrTM) catalysed the epoxidation of several para-substituted styrenes as the first enzyme showing high (R)-enantioselectivity and high conversion, demonstrated a broad substrate range, and showed high enantioselectivity for the epoxidation of an unconjugated 1,1-disubstituted alkene, 2-methyl-3-phenyl-1-propene, and a cyclic alkene, N-phenoxycarbonyl-1,2,5,6-tetrahydropyridine, respectively.

Graphical abstract: Engineered P450pyr monooxygenase for asymmetric epoxidation of alkenes with unique and high enantioselectivity

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Publication details

The article was received on 01 Sep 2013, accepted on 12 Oct 2013 and first published on 17 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46675B
Citation: Chem. Commun., 2013,49, 11572-11574
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    Engineered P450pyr monooxygenase for asymmetric epoxidation of alkenes with unique and high enantioselectivity

    A. Li, J. Liu, S. Q. Pham and Z. Li, Chem. Commun., 2013, 49, 11572
    DOI: 10.1039/C3CC46675B

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