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Issue 93, 2013
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Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

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Abstract

AmpC β-lactamase confers resistance to β-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to β-lactams.

Graphical abstract: Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

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Publication details

The article was received on 30 Aug 2013, accepted on 25 Sep 2013 and first published on 26 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC46646A
Citation: Chem. Commun., 2013,49, 10983-10985
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    Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

    M. Mondon, S. Hur, G. Vadlamani, P. Rodrigues, P. Tsybina, A. Oliver, B. L. Mark, D. J. Vocadlo and Y. Blériot, Chem. Commun., 2013, 49, 10983
    DOI: 10.1039/C3CC46646A

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