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Issue 98, 2013
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Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen

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Abstract

Inosine derivatives bearing a phosphodiester group at the O6-position of the nucleobase were synthesized via phosphitylation of the carbonyl oxygen using phosphoramidites activated by non-nucleophilic acidic activators.

Graphical abstract: Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen

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Publication details

The article was received on 29 Aug 2013, accepted on 16 Oct 2013 and first published on 17 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46617E
Citation: Chem. Commun., 2013,49, 11503-11505
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    Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen

    N. Oka, Y. Morita, Y. Itakura and K. Ando, Chem. Commun., 2013, 49, 11503
    DOI: 10.1039/C3CC46617E

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