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Issue 88, 2013
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Rescuing recombinant proteins by sequestration into the P22 VLP

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Abstract

Here we report the use of a self-assembling protein cage to sequester and solubilize recombinant proteins which are usually trafficked to insoluble inclusion bodies. Our results suggest that protein cages can be used as novel vehicles to rescue and produce soluble proteins that are otherwise difficult to obtain using conventional methods.

Graphical abstract: Rescuing recombinant proteins by sequestration into the P22 VLP

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Publication details

The article was received on 26 Aug 2013, accepted on 23 Sep 2013 and first published on 24 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC46517A
Citation: Chem. Commun., 2013,49, 10412-10414
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    Rescuing recombinant proteins by sequestration into the P22 VLP

    D. P. Patterson, B. LaFrance and T. Douglas, Chem. Commun., 2013, 49, 10412
    DOI: 10.1039/C3CC46517A

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