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Issue 95, 2013
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Trifluoromethyl ketones: properties, preparation, and application

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Abstract

Trifluoromethyl ketones (TFMKs) are exceedingly valuable synthetic targets in their own right and as synthons in the construction of fluorinated pharmacons. This Feature Article provides an overview of the properties of TFMKs, an in-depth discussion of the methods available for their synthesis, and two illustrative examples of their application as key intermediates in medicinal chemistry.

Graphical abstract: Trifluoromethyl ketones: properties, preparation, and application

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Publication details

The article was received on 15 Aug 2013, accepted on 11 Oct 2013 and first published on 14 Oct 2013


Article type: Feature Article
DOI: 10.1039/C3CC46266H
Citation: Chem. Commun., 2013,49, 11133-11148
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    Trifluoromethyl ketones: properties, preparation, and application

    C. B. Kelly, M. A. Mercadante and N. E. Leadbeater, Chem. Commun., 2013, 49, 11133
    DOI: 10.1039/C3CC46266H

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