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Issue 93, 2013
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Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution

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Abstract

Designer cells for a synthetic cascade reaction harnessing selective redox reactions were devised, featuring two successive regioselective P450-catalyzed CH-activating oxidations of 1-cyclohexene carboxylic acid methyl ester followed by stereoselective olefin-reduction catalysed by (R)- or (S)-selective mutants of an enoate reductase.

Graphical abstract: Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution

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Publication details

The article was received on 14 Aug 2013, accepted on 30 Sep 2013 and first published on 01 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46229C
Citation: Chem. Commun., 2013,49, 10914-10916
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    Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution

    R. Agudo and M. T. Reetz, Chem. Commun., 2013, 49, 10914
    DOI: 10.1039/C3CC46229C

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