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Issue 95, 2013
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Degradation of human hemoglobin by organic C-nitroso compounds

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Abstract

The crystal structure of the nitrosomethane adduct of human Hb shows N-binding of the MeNO ligands to heme Fe. The structure of the EtNO adduct reveals a surprising 4.9 Å heme slippage in the β subunit, and explains the ability of C-nitroso compounds to degrade Hb removing it from circulation.

Graphical abstract: Degradation of human hemoglobin by organic C-nitroso compounds

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Publication details

The article was received on 13 Aug 2013, accepted on 15 Oct 2013 and first published on 17 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46174B
Citation: Chem. Commun., 2013,49, 11179-11181
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    Degradation of human hemoglobin by organic C-nitroso compounds

    J. Yi, G. Ye, L. M. Thomas and G. B. Richter-Addo, Chem. Commun., 2013, 49, 11179
    DOI: 10.1039/C3CC46174B

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