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Issue 88, 2013
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A novel protecting group methodology for syntheses using nitroxides

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Abstract

The methoxyamine group represents an ideal protecting group for the nitroxide moiety. It can be easily and selectively introduced in high yield (typically >90%) to a range of functionalised nitroxides using FeSO4·7H2O and H2O2 in DMSO. Its removal is readily achieved under mild conditions in high yield (70–90%) using mCPBA in a Cope-type elimination process.

Graphical abstract: A novel protecting group methodology for syntheses using nitroxides

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Publication details

The article was received on 12 Aug 2013, accepted on 20 Sep 2013 and first published on 20 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC46146G
Citation: Chem. Commun., 2013,49, 10382-10384
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    A novel protecting group methodology for syntheses using nitroxides

    B. A. Chalmers, J. C. Morris, K. E. Fairfull-Smith, R. S. Grainger and S. E. Bottle, Chem. Commun., 2013, 49, 10382
    DOI: 10.1039/C3CC46146G

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