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Issue 94, 2013
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A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport

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Abstract

We report here a method that utilizes a photoactivatable drug–caged fluorophore conjugate to quantify intracellular drug trafficking processes at single cell resolution. Photoactivation is performed in labeled cellular compartments to visualize intracellular drug exchange under physiological conditions, without the need for washing, facilitating its translation into in vivo cancer models.

Graphical abstract: A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport

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Publication details

The article was received on 09 Aug 2013, accepted on 03 Oct 2013 and first published on 03 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46089D
Citation: Chem. Commun., 2013,49, 11050-11052
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    A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport

    S. S. Agasti, A. M. Laughney, R. H. Kohler and R. Weissleder, Chem. Commun., 2013, 49, 11050
    DOI: 10.1039/C3CC46089D

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