Dendrimer–folate–copper conjugates as bioprobes for synchrotron X-ray fluorescence imaging

Yuanqing Zhang; Xiaoping Xu; Lu Wang; Jun Lin; Ying Zhu; Zhi Guo; Yanhong Sun; Hua Wang; Yun Zhao; Renzhong Tai; Xiaohan Yu; Chunhai Fan; Qing Huang

doi:10.1039/C3CC46057F

Dendrimer–folate–copper conjugates as bioprobes for synchrotron X-ray fluorescence imaging†

Yuanqing Zhang,‡^a Xiaoping Xu,‡^a Lu Wang,^a Jun Lin,^a Ying Zhu,^a Zhi Guo,^a Yanhong Sun,*^a Hua Wang,^a Yun Zhao,^b Renzhong Tai,^a Xiaohan Yu,^a Chunhai Fan^a and Qing Huang*^a

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^a Division of Physical Biology, Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
E-mail: huangqing@sinap.ac.cn, sunyanhong@sinap.ac.cn

^b School of Life Sciences, Sichuan University, Chengdu 610065, China

Abstract

We present a bioprobe for synchrotron X-ray fluorescence imaging based on dendrimer–folate–copper conjugates. The metal nanoclusters within a dendrimer exhibit excellent FR-targeting properties in KB cells. It could be used as a new multifunction bioprobe for synchrotron X-ray fluorescence mapping.

Chemical Communications

Dendrimer–folate–copper conjugates as bioprobes for synchrotron X-ray fluorescence imaging†

Abstract

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Dendrimer–folate–copper conjugates as bioprobes for synchrotron X-ray fluorescence imaging

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