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Issue 5, 2014
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Synthesis of 3-((trifluoromethyl)thio)indoles via a reaction of 2-alkynylaniline with trifluoromethanesulfanylamide

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Abstract

3-((Trifluoromethyl)thio)indoles can be synthesized by a palladium(II)-catalyzed reaction of 2-alkynylaniline with trifluoromethanesulfanylamide in the presence of bismuth(III) chloride. The presence of bismuth(III) chloride is crucial for the success of this transformation, which activates the trifluoromethanesulfanylamide during the reaction.

Graphical abstract: Synthesis of 3-((trifluoromethyl)thio)indoles via a reaction of 2-alkynylaniline with trifluoromethanesulfanylamide

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Publication details

The article was received on 05 Aug 2013, accepted on 18 Oct 2013 and first published on 21 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC45958F
Citation: Chem. Commun., 2014,50, 578-580
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    Synthesis of 3-((trifluoromethyl)thio)indoles via a reaction of 2-alkynylaniline with trifluoromethanesulfanylamide

    J. Sheng, S. Li and J. Wu, Chem. Commun., 2014, 50, 578
    DOI: 10.1039/C3CC45958F

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