Issue 87, 2013

Recent efforts to construct the B-ring of bryostatins

Abstract

Among macrocyclic natural products, bryostatins have excellent bioactivities and unique structures that make them highly attractive to synthetic chemists. Particularly challenging for the total synthesis of bryostatins is the B-ring, which features a cis-tetrahydropyran containing a geometrically defined exocyclic Z-methyl enoate. Synthetic chemists have recently displayed great prowess in their efforts to construct this ring, and here we summarize the progress towards this goal.

Graphical abstract: Recent efforts to construct the B-ring of bryostatins

Article information

Article type
Feature Article
Submitted
04 Aug 2013
Accepted
03 Sep 2013
First published
03 Sep 2013

Chem. Commun., 2013,49, 10211-10220

Recent efforts to construct the B-ring of bryostatins

L. Gao, J. Lu and Z. Song, Chem. Commun., 2013, 49, 10211 DOI: 10.1039/C3CC45947K

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