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Issue 88, 2013
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Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans

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Abstract

Adhesion on a surface via nonspecific attachment or multiple ligand–receptor interactions is a critical event for fungal infection by Candida albicans. Here, we find that the tri(ethylene glycol)- and D-mannitol-terminated monolayers do not resist the blastospore attachment, but prevent the hyphae adhesion of C. albicans. The hyphae adhesion can be facilitated by tripeptide sequences of arginine–glycine–aspartic acid (RGD) covalently decorated on a background of tri(ethylene glycol)-terminated monolayers. This adhesion mediated by selected ligands is sensitive to the scrambling of peptide sequences, and is inhibited by the presence of cyclic RGD peptides in the solution.

Graphical abstract: Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans

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Publication details

The article was received on 03 Aug 2013, accepted on 18 Sep 2013, published on 18 Sep 2013 and first published online on 18 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC45945D
Citation: Chem. Commun., 2013,49, 10418-10420
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    Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans

    N. Varghese, S. Yang, P. Sejwal and Y. Luk, Chem. Commun., 2013, 49, 10418
    DOI: 10.1039/C3CC45945D

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