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Issue 98, 2013
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[3-(Trifluoromethyl)-3H-diazirin-3-yl]coumarin as a carbene-generating photocross-linker with masked fluorogenic beacon

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Abstract

A coumarin-fused diazirine photolabeling agent exhibited dramatic enhancement in fluorescence after cross-linking with the target protein. Fluorescence emission from the coumarin moiety was efficiently quenched by the diazirine group, and was then intensively recovered from photolysis treatment by irradiation with light at a wavelength of 365 nm.

Graphical abstract: [3-(Trifluoromethyl)-3H-diazirin-3-yl]coumarin as a carbene-generating photocross-linker with masked fluorogenic beacon

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Publication details

The article was received on 29 Jul 2013, accepted on 15 Oct 2013, published on 17 Oct 2013 and first published online on 17 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC45780J
Citation: Chem. Commun., 2013,49, 11551-11553
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    [3-(Trifluoromethyl)-3H-diazirin-3-yl]coumarin as a carbene-generating photocross-linker with masked fluorogenic beacon

    T. Tomohiro, A. Yamamoto, Y. Tatsumi and Y. Hatanaka, Chem. Commun., 2013, 49, 11551
    DOI: 10.1039/C3CC45780J

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