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Issue 80, 2013
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A graphene oxide-based platform for the assay of RNA synthesis by RNA polymerase using a fluorescent peptide nucleic acid probe

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Abstract

We report a simple, direct fluorometric assay based on graphene oxide (GO) for RNA polymerase-mediated RNA synthesis. In principle, fluorescent peptide nucleic acid (PNA) probes were designed, and annealed with RNA products and the resultant RNA–PNA hybrids induced the recovery of fluorescence intensity of the PNA probes adsorbed onto the GO surface.

Graphical abstract: A graphene oxide-based platform for the assay of RNA synthesis by RNA polymerase using a fluorescent peptide nucleic acid probe

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Publication details

The article was received on 27 Jul 2013, accepted on 07 Aug 2013 and first published on 07 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45750H
Citation: Chem. Commun., 2013,49, 9203-9205
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    A graphene oxide-based platform for the assay of RNA synthesis by RNA polymerase using a fluorescent peptide nucleic acid probe

    J. S. Park, A. Baek, I. Park, B. Jun and D. Kim, Chem. Commun., 2013, 49, 9203
    DOI: 10.1039/C3CC45750H

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