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Issue 96, 2013
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Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks

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Abstract

A series of new zinc-based metal–organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.

Graphical abstract: Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks

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Publication details

The article was received on 25 Jul 2013, accepted on 09 Oct 2013 and first published on 17 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC45689G
Citation: Chem. Commun., 2013,49, 11260-11262
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    Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks

    A. D. Burrows, M. Jurcic, L. L. Keenan, R. A. Lane, M. F. Mahon, M. R. Warren, H. Nowell, M. Paradowski and J. Spencer, Chem. Commun., 2013, 49, 11260
    DOI: 10.1039/C3CC45689G

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