Issue 88, 2013
From the journal:

Chemical Communications

Molecular design for enhanced sensitivity of a FRET aptasensor built on the graphene oxide surface†

Yuko Ueno,*a   Kazuaki Furukawa,b   Kota Matsuo,‡a   Suzuyo Inoue,a   Katsuyoshi Hayashia  and  Hiroki Hibinob  

* Corresponding authors

a NTT Microsystem Integration Laboratories, NTT Corporation, 3-1 Morinosato Wakamiya, Atsugi, Kanagawa, Japan
E-mail: ueno.yuko@lab.ntt.co.jp
Fax: +81-46-240-4728
Tel: +81-46-240-3549

b NTT Basic Research Laboratories, NTT Corporation, Atsugi, Kanagawa, Japan

Abstract

We designed a biomolecular probe for highly sensitive protein detection by modifying an aptamer with a DNA spacer. The spacer controls the distance between a fluorescence dye and a quencher, which is crucial for FRET-based sensors. We successfully demonstrated an improvement in the sensitivity of an on-chip graphene oxide aptasensor.

Graphical abstract: Molecular design for enhanced sensitivity of a FRET aptasensor built on the graphene oxide surface

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Article information

DOI
https://doi.org/10.1039/C3CC45615C
Article type
Communication
Submitted
24 Jul 2013
Accepted
08 Aug 2013
First published
09 Aug 2013

Chem. Commun., 2013,49, 10346-10348

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Molecular design for enhanced sensitivity of a FRET aptasensor built on the graphene oxide surface

Y. Ueno, K. Furukawa, K. Matsuo, S. Inoue, K. Hayashi and H. Hibino, Chem. Commun., 2013, 49, 10346 DOI: 10.1039/C3CC45615C

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