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Issue 77, 2013
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Direct asymmetric syntheses of chiral aldehydes and ketones via N-acyl chiral auxiliary derivatives including chiral Weinreb amide equivalents

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Abstract

This article covers N-acyl chiral auxiliary-based approaches to the asymmetric synthesis of enantiopure aldehydes and ketones. The use of diastereoisomerically pure N-acyl derivatives of chiral auxiliaries (including chiral Weinreb amide equivalents) and their conversion to the corresponding enantiopure aldehydes and ketones in a single synthetic operation by treatment with a hydride reducing agent or an organometallic reagent, respectively, are highlighted.

Graphical abstract: Direct asymmetric syntheses of chiral aldehydes and ketones via N-acyl chiral auxiliary derivatives including chiral Weinreb amide equivalents

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Publication details

The article was received on 18 Jul 2013, accepted on 06 Aug 2013 and first published on 08 Aug 2013


Article type: Feature Article
DOI: 10.1039/C3CC45463K
Citation: Chem. Commun., 2013,49, 8586-8598
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    Direct asymmetric syntheses of chiral aldehydes and ketones via N-acyl chiral auxiliary derivatives including chiral Weinreb amide equivalents

    S. G. Davies, A. M. Fletcher and J. E. Thomson, Chem. Commun., 2013, 49, 8586
    DOI: 10.1039/C3CC45463K

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