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Issue 82, 2013
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Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine

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Abstract

The reaction between cisplatin and DNA is conveniently studied using fluorescently labeled oligonucleotides and gel electrophoresis; as an example of application, the inhibition of this reaction by citrate is demonstrated, which might increase selectivity of cisplatin towards guanine over adenine.

Graphical abstract: Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine

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Publication details

The article was received on 18 Jul 2013, accepted on 16 Aug 2013 and first published on 19 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45458D
Citation: Chem. Commun., 2013,49, 9482-9484
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    Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine

    F. Wang, P. J. Huang and J. Liu, Chem. Commun., 2013, 49, 9482
    DOI: 10.1039/C3CC45458D

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