Issue 81, 2013

Non-enzymatic acylative kinetic resolution of primary allylic amines

Abstract

A non-enzymatic acetyl transfer-based kinetic resolution of primary allylic amines is reported. The process involves the use of (1S,2S)-1 in conjunction with a supported ammonium salt and affords the corresponding enantio-enriched N-acetylated allylic amines with unprecedented levels of selectivity (s-factors up to 34).

Graphical abstract: Non-enzymatic acylative kinetic resolution of primary allylic amines

Supplementary files

Article information

Article type
Communication
Submitted
18 Jul 2013
Accepted
13 Aug 2013
First published
14 Aug 2013

Chem. Commun., 2013,49, 9338-9340

Non-enzymatic acylative kinetic resolution of primary allylic amines

A. Kolleth, M. Cattoen, S. Arseniyadis and J. Cossy, Chem. Commun., 2013, 49, 9338 DOI: 10.1039/C3CC45453C

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