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Issue 80, 2013
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Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

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Abstract

Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.

Graphical abstract: Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

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Publication details

The article was received on 16 Jul 2013, accepted on 08 Aug 2013 and first published on 08 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45369C
Citation: Chem. Commun., 2013,49, 9224-9226
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    Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

    X. Dou, W. Yao, B. Zhou and Y. Lu, Chem. Commun., 2013, 49, 9224
    DOI: 10.1039/C3CC45369C

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