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Issue 92, 2013
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A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: selective detection and quantification

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Abstract

A novel long-wavelength fluorescence probe NBP has been developed for the detection of nitroreductase (NTR) and hypoxia. NBP could be activated by NTR at 0.1 μM to release the fluorophore NBF and significant changes in fluorescence emission at 658 nm were observed. This feature makes it advantageous for imaging hypoxic cells with minimal endogenous interference.

Graphical abstract: A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: selective detection and quantification

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Publication details

The article was received on 16 Jul 2013, accepted on 24 Sep 2013 and first published on 25 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC45367G
Citation: Chem. Commun., 2013,49, 10820-10822
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    A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: selective detection and quantification

    T. Guo, L. Cui, J. Shen, W. Zhu, Y. Xu and X. Qian, Chem. Commun., 2013, 49, 10820
    DOI: 10.1039/C3CC45367G

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