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Issue 81, 2013
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One-pot total chemical synthesis of human α-synuclein

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Abstract

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

Graphical abstract: One-pot total chemical synthesis of human α-synuclein

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Publication details

The article was received on 15 Jul 2013, accepted on 02 Aug 2013 and first published on 02 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45353G
Citation: Chem. Commun., 2013,49, 9254-9256
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    One-pot total chemical synthesis of human α-synuclein

    B. Fauvet, S. M. Butterfield, J. Fuks, A. Brik and H. A. Lashuel, Chem. Commun., 2013, 49, 9254
    DOI: 10.1039/C3CC45353G

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