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An efficient route to chiral N-heterocycles bearing a C–F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines

Ran-Ning Guo,a   Xian-Feng Cai,a   Lei Shi,a   Zhi-Shi Ye,a   Mu-Wang Chena and   Yong-Gui Zhou*a  
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a
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
E-mail: ygzhou@dicp.ac.cn
Chem. Commun., 2013,49, 8537-8539

DOI: 10.1039/C3CC45341C
Received 15 Jul 2013, Accepted 22 Jul 2013
First published online 22 Jul 2013
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