Issue 88, 2013
From the journal:

Chemical Communications

Design, synthesis and evaluation of a boronic acid based artificial receptor for l-DOPA in aqueous media†

Haruna Ueno,a   Takayuki Iwata,a   Nozomi Koshiba,a   Daisuke Takahashi*a  and  Kazunobu Toshima*a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
E-mail: dtak@applc.keio.ac.jp, toshima@applc.keio.ac.jp
Fax: +81 45-566-1576

Abstract

Design and synthesis of a boronic acid based artificial receptor which selectively and effectively bound to a neurotransmitter, L-DOPA (1), in aqueous media. In addition, the synthetic receptor was found to effectively inhibit the DDC (L-DOPA decarboxylase) enzymatic reaction under physiological conditions.

Graphical abstract: Design, synthesis and evaluation of a boronic acid based artificial receptor for l-DOPA in aqueous media

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Article information

DOI
https://doi.org/10.1039/C3CC45275A
Article type
Communication
Submitted
12 Jul 2013
Accepted
16 Sep 2013
First published
17 Sep 2013

Chem. Commun., 2013,49, 10403-10405

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Design, synthesis and evaluation of a boronic acid based artificial receptor for L-DOPA in aqueous media

H. Ueno, T. Iwata, N. Koshiba, D. Takahashi and K. Toshima, Chem. Commun., 2013, 49, 10403 DOI: 10.1039/C3CC45275A

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