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Issue 78, 2013
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Development of an expedient intramolecular Pauson–Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center

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Abstract

Stereoselective synthesis of the trans-decalin subunit with a defined C1 quaternary chiral center has been achieved by the Pauson–Khand reaction (PKR) as a key step. The developed chemistry offers an alternative to the IMDA reaction that has been used for the syntheses of trans-decalin based biologically active natural products.

Graphical abstract: Development of an expedient intramolecular Pauson–Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center

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Publication details

The article was received on 11 Jul 2013, accepted on 31 Jul 2013 and first published on 01 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45170D
Citation: Chem. Commun., 2013,49, 8806-8808
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    Development of an expedient intramolecular Pauson–Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center

    L. Shi, H. Shen, L. Fang, J. Huang, C. Li and Z. Yang, Chem. Commun., 2013, 49, 8806
    DOI: 10.1039/C3CC45170D

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