Issue 85, 2013

A suspension-cell biosensor for real-time determination of binding kinetics of protein–carbohydrate interactions on cancer cell surfaces

Abstract

A novel lectin-based suspension-cell biosensor for label-free determination of binding kinetics of proteincarbohydrate interactions on cancer cell surfaces using QCM is described. This cell-biosensor facilitates evaluation of glycosylation in real time on suspension cancer cell surfaces, where binding events take place, more closely mimicking a native environment compared with traditional biosensors.

Graphical abstract: A suspension-cell biosensor for real-time determination of binding kinetics of protein–carbohydrate interactions on cancer cell surfaces

Supplementary files

Article information

Article type
Communication
Submitted
03 Jul 2013
Accepted
30 Jul 2013
First published
31 Jul 2013

Chem. Commun., 2013,49, 9908-9910

A suspension-cell biosensor for real-time determination of binding kinetics of proteincarbohydrate interactions on cancer cell surfaces

X. Li, Y. Pei, R. Zhang, Q. Shuai, F. Wang, T. Aastrup and Z. Pei, Chem. Commun., 2013, 49, 9908 DOI: 10.1039/C3CC45006F

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