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Issue 85, 2013
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CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents

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The first examples of air-stable CoII paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.

Graphical abstract: CoCEST: cobalt(ii) amide-appended paraCEST MRI contrast agents

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Publication details

The article was received on 04 Jul 2013, accepted on 02 Sep 2013 and first published on 17 Sep 2013

Article type: Communication
DOI: 10.1039/C3CC45000G
Citation: Chem. Commun., 2013,49, 10025-10027
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    CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents

    S. J. Dorazio, A. O. Olatunde, J. A. Spernyak and J. R. Morrow, Chem. Commun., 2013, 49, 10025
    DOI: 10.1039/C3CC45000G

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