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Issue 76, 2013
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Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent

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Abstract

The bi-functional complex [PtII(terpy)(py-naphth)](NO3)2(1), incorporating both 2,2′:6′,2′′-terpyridine and 4-N,N′-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.

Graphical abstract: Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent

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Publication details

The article was received on 02 Jul 2013, accepted on 01 Aug 2013 and first published on 01 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC44962A
Citation: Chem. Commun., 2013,49, 8522-8524
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    Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent

    S. Banerjee, J. A. Kitchen, S. A. Bright, J. E. O'Brien, D. C. Williams, J. M. Kelly and T. Gunnlaugsson, Chem. Commun., 2013, 49, 8522
    DOI: 10.1039/C3CC44962A

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