Issue 91, 2013

A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers

Abstract

We engineered the structural flexibility of an α synuclein (αS) variant, PG65, together with conformation-sensitive fluorescence to create a molecular probe for rapid, specific and quantitative detection of αS oligomers, which are the major toxic aggregate forms in Parkinson’s disease.

Graphical abstract: A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers

Supplementary files

Article information

Article type
Communication
Submitted
26 Jun 2013
Accepted
23 Sep 2013
First published
26 Sep 2013

Chem. Commun., 2013,49, 10712-10714

A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers

M. Hernandez, Y. Hu and J. R. Kim, Chem. Commun., 2013, 49, 10712 DOI: 10.1039/C3CC44804E

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