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Issue 76, 2013
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Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

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Abstract

The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.

Graphical abstract: Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

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Publication details

The article was received on 24 Jun 2013, accepted on 30 Jul 2013 and first published on 31 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC44737E
Citation: Chem. Commun., 2013,49, 8453-8455
  • Open access: Creative Commons BY-NC license
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    Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

    P. Murat, M. V. Gormally, D. Sanders, M. D. Antonio and S. Balasubramanian, Chem. Commun., 2013, 49, 8453
    DOI: 10.1039/C3CC44737E

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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      [Original citation] - Published by The Royal Society of Chemistry.

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