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Issue 70, 2013
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Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

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Abstract

An efficient synthesis of racemic or optically active α-amino acids by modified-Mitsunobu alkylation of a racemic or chiral glycine template from alcohols was developed. Libraries of amino acids were prepared in moderate to good yield with good to high enantioselectivity. This simple method widens the scope for preparation of structurally diverse amino acids.

Graphical abstract: Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

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Publication details

The article was received on 23 Jun 2013, accepted on 10 Jul 2013 and first published on 12 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC44717K
Citation: Chem. Commun., 2013,49, 7744-7746
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    Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

    A. F. M. Noisier, C. S. Harris and M. A. Brimble, Chem. Commun., 2013, 49, 7744
    DOI: 10.1039/C3CC44717K

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