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Issue 80, 2013
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Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

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Abstract

We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off–on fluorescent sensing of the properly folded quaternary structure of TTR.

Graphical abstract: Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

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Publication details

The article was received on 21 Jun 2013, accepted on 06 Aug 2013 and first published on 07 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC44667K
Citation: Chem. Commun., 2013,49, 9188-9190
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    Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

    N. Myung, S. Connelly, B. Kim, S. J. Park, I. A. Wilson, J. W. Kelly and S. Choi, Chem. Commun., 2013, 49, 9188
    DOI: 10.1039/C3CC44667K

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