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Issue 71, 2013
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Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides

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Abstract

Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a high selectivity.

Graphical abstract: Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides

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Publication details

The article was received on 13 Jun 2013, accepted on 03 Jul 2013 and first published on 04 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC44434A
Citation: Chem. Commun., 2013,49, 7809-7811
  • Open access: Creative Commons BY-NC license
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    Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides

    Y. Miyake, S. Ota, M. Shibata, K. Nakajima and Y. Nishibayashi, Chem. Commun., 2013, 49, 7809
    DOI: 10.1039/C3CC44434A

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