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Issue 74, 2013
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Antioxidant generation and regeneration in lipid bilayers: the amazing case of lipophilic thiosulfinates and hydrophilic thiols

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Abstract

We demonstrate that the garlic-derived chemopreventive agent allicin and the related anamu-derived petivericin are poor radical-trapping antioxidants in lipid bilayers, but that the in situ reaction of a lipophilic analog and a hydrophilic thiol yields an extremely potent radical-trapping antioxidant that can be recycled in the presence of excess thiol.

Graphical abstract: Antioxidant generation and regeneration in lipid bilayers: the amazing case of lipophilic thiosulfinates and hydrophilic thiols

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Publication details

The article was received on 11 Jun 2013, accepted on 01 Aug 2013 and first published on 02 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC44401E
Citation: Chem. Commun., 2013,49, 8181-8183
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    Antioxidant generation and regeneration in lipid bilayers: the amazing case of lipophilic thiosulfinates and hydrophilic thiols

    F. Zheng and D. A. Pratt, Chem. Commun., 2013, 49, 8181
    DOI: 10.1039/C3CC44401E

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