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Issue 73, 2013
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Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

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Abstract

Transition metal complexes allow fine tuning of DNA binding affinity and selectivity. Here we report on the nucleic acid recognition properties of a phenanthroline-based ligand coordinated to Ni2+ or Cu2+. The resulting complexes clearly bind to telomeric G-quadruplexes at different sites according to the nature of the bound metal ion.

Graphical abstract: Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

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Publication details

The article was received on 11 Jun 2013, accepted on 17 Jul 2013 and first published on 18 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC44382E
Citation: Chem. Commun., 2013,49, 8057-8059
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    Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

    S. Bianco, C. Musetti, A. P. Krapcho, M. Palumbo and C. Sissi, Chem. Commun., 2013, 49, 8057
    DOI: 10.1039/C3CC44382E

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