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Issue 86, 2013
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Copper mediated stereoselective synthesis of C-glycosides from unactivated alkynes

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Abstract

A highly stereoselective rapid C-glycosylation reaction has been developed between glycal and unactivated alkynes in the presence of coppertriflate and ascorbic acid at low catalyst loading and at room temperature. A wide variety of glycals and aryl acetylenes participate in the reaction smoothly. TfOH generated during the reduction of Cu(OTf)2 by ascorbic acid may be the active catalyst for the glycosylation.

Graphical abstract: Copper mediated stereoselective synthesis of C-glycosides from unactivated alkynes

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Publication details

The article was received on 05 Jun 2013, accepted on 19 Aug 2013 and first published on 21 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC44250K
Citation: Chem. Commun., 2013,49, 10154-10156
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    Copper mediated stereoselective synthesis of C-glycosides from unactivated alkynes

    A. K. Kusunuru, M. Tatina, S. K. Yousuf and D. Mukherjee, Chem. Commun., 2013, 49, 10154
    DOI: 10.1039/C3CC44250K

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