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Issue 68, 2013
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Oxidative cross-coupling/cyclization to build polysubstituted pyrroles from terminal alkynes and β-enamino esters

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Abstract

A novel silver-mediated highly selective synthesis of polysubstituted pyrroles by the C–H/C–H oxidative cross-coupling/cyclization of terminal alkynes with β-enamino esters has been developed. This protocol represents a simple, efficient and selective way to construct polysubstituted pyrroles in good yields from basic chemical materials.

Graphical abstract: Oxidative cross-coupling/cyclization to build polysubstituted pyrroles from terminal alkynes and β-enamino esters

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Publication details

The article was received on 16 May 2013, accepted on 24 Jun 2013 and first published on 25 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC43682A
Citation: Chem. Commun., 2013,49, 7549-7551
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    Oxidative cross-coupling/cyclization to build polysubstituted pyrroles from terminal alkynes and β-enamino esters

    J. Ke, C. He, H. Liu, M. Li and A. Lei, Chem. Commun., 2013, 49, 7549
    DOI: 10.1039/C3CC43682A

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