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Issue 71, 2013
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Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp3 C–O bond cleavage

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Abstract

The first iron-catalyzed formal cross coupling of homobenzylic methyl ethers with alkyl Grignard reagents is realized. The reaction is proposed to proceed through a sequence of dehydroalkoxylation to form the vinyl-intermediate, followed by Fe-catalyzed selective carbometalation to form a benzylic Grignard reagent.

Graphical abstract: Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp3 C–O bond cleavage

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Publication details

The article was received on 14 May 2013, accepted on 02 Jul 2013 and first published on 02 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC43616K
Citation: Chem. Commun., 2013,49, 7794-7796
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    Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp3 C–O bond cleavage

    S. Luo, D. Yu, R. Zhu, X. Wang, L. Wang and Z. Shi, Chem. Commun., 2013, 49, 7794
    DOI: 10.1039/C3CC43616K

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