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Issue 76, 2013
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An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration

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Abstract

19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving them potential for use as molecular therapeutics in cancer and neurodegeneration. Here a new method of synthesising these important compounds is reported, eliminating the need for toxic metals and metalloids.

Graphical abstract: An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration

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Publication details

The article was received on 09 May 2013, accepted on 10 Jun 2013 and first published on 10 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC43457E
Citation: Chem. Commun., 2013,49, 8441-8443
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    An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration

    R. R. A. Kitson and C. J. Moody, Chem. Commun., 2013, 49, 8441
    DOI: 10.1039/C3CC43457E

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