Atomic-scale structures and interactions between the guanine quartet and potassium

Wei Xu; Qinggang Tan; Miao Yu; Qiang Sun; Huihui Kong; Erik Lægsgaard; Ivan Stensgaard; Jørgen Kjems; Jian-guo Wang; Chen Wang; Flemming Besenbacher

doi:10.1039/C3CC43302A

Atomic-scale structures and interactions between the guanine quartet and potassium

Wei Xu,*^ab Qinggang Tan,^a Miao Yu,^b Qiang Sun,^a Huihui Kong,^a Erik Lægsgaard,^b Ivan Stensgaard,^b Jørgen Kjems,^b Jian-guo Wang,*^c Chen Wang^d and Flemming Besenbacher*^b

Author affiliations

* Corresponding authors

^a College of Materials Science and Engineering, Key Laboratory for Advanced Civil Engineering Materials (Ministry of Education), Tongji University, Caoan Road 4800, Shanghai 201804, P. R. China
E-mail: xuwei@tongji.edu.cn

^b Interdisciplinary Nanoscience Center (iNANO), Center for DNA Nanotechnology (CDNA), Department of Physics and Astronomy, and Department of Molecular Biology, Aarhus University, DK 8000 Aarhus C, Denmark
E-mail: fbe@inano.au.dk

^c Institute of Industrial Catalysis, College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou, P. R. China
E-mail: jgw@zjut.edu.cn

^d National Center for Nanoscience and Technology, Beijing 100190, P. R. China

Abstract

The atomic-scale identification of the G₄K₁ structural motif is achieved using an interplay of STM imaging and DFT calculations. Its high stability is found to be caused by the delicate balance between hydrogen bonding and metal–ligand interaction, which is of utmost relevance to model interactions of the G-quadruplex with cations in vivo.

Chemical Communications

Atomic-scale structures and interactions between the guanine quartet and potassium

Abstract

Article information

Download Citation

Permissions

Atomic-scale structures and interactions between the guanine quartet and potassium

Social activity

Search articles by author

Spotlight

Advertisements