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Issue 54, 2013
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Side chain and backbone structure-dependent subcellular localization and toxicity of conjugated polymer nanoparticles

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Abstract

The subcellular localization and toxicity of conjugated polymer nanoparticles (CPNs) are dependent on the chemical structure of the side chains and backbone. Primary amine-containing CPNs exhibit high Golgi localization with no toxicity. Incorporation of short ethylene oxide and tertiary amine side chains contributes to decreased Golgi localization and increased toxicity, respectively.

Graphical abstract: Side chain and backbone structure-dependent subcellular localization and toxicity of conjugated polymer nanoparticles

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Publication details

The article was received on 23 Apr 2013, accepted on 16 May 2013 and first published on 16 May 2013


Article type: Communication
DOI: 10.1039/C3CC43015D
Citation: Chem. Commun., 2013,49, 6048-6050
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    Side chain and backbone structure-dependent subcellular localization and toxicity of conjugated polymer nanoparticles

    E. Mendez and J. H. Moon, Chem. Commun., 2013, 49, 6048
    DOI: 10.1039/C3CC43015D

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