Issue 58, 2013

Three-component reaction of small-ring cyclic amines with arynes and acetonitrile

Abstract

A novel stereospecific three-component reaction of aziridines and azetidines with arynes and acetonitrile has been developed. The reaction affords N-aryl γ-aminobutyronitriles and δ-aminovaleronitriles that can be used as precursors and congeners of a number of bioactive compounds, such as pregabalin and lergotrile.

Graphical abstract: Three-component reaction of small-ring cyclic amines with arynes and acetonitrile

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2013
Accepted
30 May 2013
First published
30 May 2013

Chem. Commun., 2013,49, 6558-6560

Three-component reaction of small-ring cyclic amines with arynes and acetonitrile

D. Stephens, Y. Zhang, M. Cormier, G. Chavez, H. Arman and O. V. Larionov, Chem. Commun., 2013, 49, 6558 DOI: 10.1039/C3CC42854K

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