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Issue 51, 2013
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Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease

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Abstract

Partially reduced oxygen species (PROS), produced by reduced heme bound Aβ peptides, can cause oxidative stress and synaptic damage in the brain, which is one of the key pathological features of Alzheimer's disease. In situ oxidation of the heme center by a physiological redox agent like Cytochrome c (Cyt c) can significantly suppress neurotoxic PROS formation. Thus, Cyt c can potentially act as a neuroprotective agent against AD.

Graphical abstract: Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease

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Publication details

The article was received on 12 Apr 2013, accepted on 03 May 2013 and first published on 03 May 2013


Article type: Communication
DOI: 10.1039/C3CC42700E
Citation: Chem. Commun., 2013,49, 5754-5756
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    Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease

    C. Ghosh, S. Mukherjee and S. G. Dey, Chem. Commun., 2013, 49, 5754
    DOI: 10.1039/C3CC42700E

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