Issue 51, 2013
From the journal:

Chemical Communications

Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease†

Chandradeep Ghosh,a   Soumya Mukherjeea  and  Somdatta Ghosh Dey*a  

* Corresponding authors

a Indian Association for the Cultivation of Science, Department of Inorganic Chemistry, 2A & 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata, India
E-mail: icsgd@iacs.res.in
Fax: +91-33-2473-2805/2483-656

Abstract

Partially reduced oxygen species (PROS), produced by reduced heme bound Aβ peptides, can cause oxidative stress and synaptic damage in the brain, which is one of the key pathological features of Alzheimer's disease. In situ oxidation of the heme center by a physiological redox agent like Cytochrome c (Cyt c) can significantly suppress neurotoxic PROS formation. Thus, Cyt c can potentially act as a neuroprotective agent against AD.

Graphical abstract: Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C3CC42700E
Article type
Communication
Submitted
12 Apr 2013
Accepted
03 May 2013
First published
03 May 2013

Chem. Commun., 2013,49, 5754-5756

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Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease

C. Ghosh, S. Mukherjee and S. G. Dey, Chem. Commun., 2013, 49, 5754 DOI: 10.1039/C3CC42700E

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