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Issue 57, 2013
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A novel class of polymeric pH-responsive MRI CEST agents

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Abstract

In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially “off” when the polymers form micelles near physiological pH but is activated to the “on” state when the micelles dissociate in an acidic environment.

Graphical abstract: A novel class of polymeric pH-responsive MRI CEST agents

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Publication details

The article was received on 04 Apr 2013, accepted on 26 May 2013 and first published on 28 May 2013


Article type: Communication
DOI: 10.1039/C3CC42452A
Citation: Chem. Commun., 2013,49, 6418-6420
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    A novel class of polymeric pH-responsive MRI CEST agents

    S. Zhang, K. Zhou, G. Huang, M. Takahashi, A. Dean Sherry and J. Gao, Chem. Commun., 2013, 49, 6418
    DOI: 10.1039/C3CC42452A

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